Dr. Oliver Bracko was born in Germany and studied at the University of Tübingen. He received his Ph.D. from the ETH Zürich in Switzerland and did his postdoc at Cornell University under the mentorship of Chris Schaffer. His previous research was focused on adult neuronal stem cells and the impact of stroke on cognitive function.
My research focuses on elucidating common mechanisms of cognitive decline in neurodegenerative disease. We employ high resolution in vivo multiphoton imaging and animal behavior in mouse models to identify novel mechanisms connecting neurodegenerative diseases. This approach allows us to follow complex physiological processes on both cellular and organ (brain, tissue) scales. Currently, we are focusing on capillary stalling as a novel phenomenon explaining a large proportion of the reduced brain blood flow seen in mouse models of Alzheimer’s disease. These capillary stalls are primarily comprised of leukocytes firmly bound to endothelial cells that lead to transiently block capillaries and reduce cortical blood flow. Furthermore, we are exploring upstream molecular mechanisms that cause this capillary stalling phenomenon, and we are determining the downstream consequences of improving brain blood flow in Alzheimer’s disease progression.
Bracko's Citations
| Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex
S tom Dieck, WD Altrock, MM Kessels, B Qualmann, H Regus, D Brauner, ...
The Journal of cell biology 168 (5), 825-836
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337 |
2005 |
| Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models
JC Cruz Hernández, O Bracko, CJ Kersbergen, V Muse, ...
Nature neuroscience 22 (3), 413-420
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265 |
2019 |
| Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis
O Bracko, T Singer, S Aigner, M Knobloch, B Winner, J Ray, ...
Journal of Neuroscience 32 (10), 3376-3387
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219 |
2012 |
| Control of lateral organ development and flowering time by the Arabidopsis thaliana MADS‐box Gene AGAMOUS‐LIKE6
SC Koo, O Bracko, MS Park, R Schwab, HJ Chun, KM Park, JS Seo, ...
The Plant Journal 62 (5), 807-816
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Website
http://www.brackolab.com.dream.website/team/
Education
| 2012 |
Ph.D. Cell Biology, Ph.D. , ETH Zurich |
| 2008 |
M.Sc. Biology, Eberhard-Karls University |
Professional Experience
| 2015 - 2021 |
Postdoctoral Researcher, Department of Biomechanical Engineering, Cornell University |
| 2012 - 2015 |
Postdoctoral Researcher, Department of Neurology, University Hospital Zurich |
